Avene A-Oxitive Antioxidant Defense Serum in Beauty: NA. Avene A-Oxitive Antioxidant Defense Serum in Beauty: NA. A-Oxitive Antioxidant Defense Serum features a complete antioxidant complex to fight against the harmful effects of oxidative stress by boosting the skin's defense for hydrated, visibly plumped skin. Pre-Tocopheryl, a stable form of Vitamin E, and Ascorbyl Glucoside, a stable form of Vitamin C, help protect skin against free radical effects and environmental stressors, while GP4G, an energizing molecule, helps optimize skin's natural defenses. This instantly refreshing, fast-absorbing serum is also infused with soothing Avene Thermal Spring Water to help restore the skin's balance, revealing a more radiant complexion.. Suitable for all skin types. Hypoallergenic, non-comedogenic and cruelty-free. Free of Soap, Parabens, Soy, Wheat, Oil, Aluminum, Talc and Silica. 1 fl oz. Apply AM/PM before moisturizer to face, neck and décolleté. AENE-WU12. P0001789. Avene has over 270 years of expertise in caring for sensitive skin and is trusted by millions worldwide. At the heart of the brand is Avene Thermal Spring Water, a natural soothing source clinically shown by over 150 studies to soothe, soften and calm the skin.